GeneTex
United States (US)

Transferrin antibody [8B9]

Cat No. GTX10212

Host Mouse
Clonality Monoclonal
Clone Name 8B9
Isotype IgG1
Application ELISA
Reactivity Human
APPLICATION

Application Note

ELISA: Use at an assay dependent dilution. Will detect transferrin in serum by sandwich ELISA as an antibody pair. Use GTX10212 as the coating agent with either GTX10208 or GTX10209 for detection. Will detect transferrin-transferrin receptor complex when used as an antibody pair with an anti-transferrin receptor antibody. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

77 kDa. ( Note )

Specificity/Sensitivity

Human transferrin
PROPERTIES

Form

Liquid

Buffer

Phosphate-buffered saline, pH 7.4, containing 0.1% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

2mg/ml(Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Placental transferrin receptor or transferrin

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

PRO1557, TF, PRO2086, 7018, P02787, Transferrin, 190000, DKFZp781D0156

Cellular Localization

Secreted

Background

Transferrin is a single polypeptide chain glycoprotein and is a member of the iron binding family of proteins. It has a molecular weight of 77 kDa and a serum concentration range of 1800 to 2700 mg/L. It is synthesized in the liver and consists of two domains each having a high affinity reversible binding site for Fe3+. The iron is transported in blood and interstitial fluids to sites of use and disposal. Iron/transferrin is essential in haemoglobin synthesis and for certain types of cell division. Serum concentration rises in iron deficiency and pregnancy and falls in iron overload, infection and inflammatory conditions. The function of transferrin is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. In addition to its function in iron transport, this protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter/allergins from serum.

Database

Research Area