APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 0.5 - 1 μg/mL |
| 5 μg/mL |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
Rat Lung Tissue Lysate(GTX27941) , Human Lung Tissue Slide
Product Note
At least two isoforms of Translin are known to exist; this antibody will detect both.
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Translin antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human Translin.The immunogen is located within the last 50 amino acids of Translin.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
translin , BCLF-1 , C3PO , RCHF1 , REHF-1 , TBRBP , TRSLN
Cellular Localization
Cytoplasm,Nucleus
Background
This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
Database
Research Area
DATA IMAGES
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GTX31440 IHC-P Image
IHC-P analysis of human lung tissue using GTX31440 Translin antibody.
Working concentration : 5 μg/ml
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GTX31440 WB Image
WB analysis of rat lung tissue lysate using GTX31440 Translin antibody.
Working concentration : (A) 0.5 and (B) 1 μg/ml
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GTX31440 IHC-P Image
IHC-P analysis of human lung tissue using GTX31440 Translin antibody.
Working concentration : 20 μg/ml
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REFERENCE
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REVIEW
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