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Transportin 1 antibody [D45]

Cat. No. GTX10303

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 D45

Isotype

 IgG1

Application

 WB, ICC/IF, IP

Reactivity

 Human, Mouse, Rat, Bovine, Dog
Package
50 μl ($399)
See all Transportin 1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.1-0.2 μg/ml
ICC/IF Assay dependent
IP Assay dependent
Not tested in other applications.

Calculated MW

102 kDa. ( Note )

Positive Control

HeLa nuclear extract

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA

Preservative

15mM Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

recombinant human transportin 1.

Purification

Purified immunoglobulin

Conjugation

Unconjugated

RRID

AB_380980

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

transportin 1 , IPO2 , KPNB2 , MIP , MIP1 , TRN

Cellular Localization

Cytoplasm,Nucleus

Background

Heterogeneous nuclear ribonucleoprotein hnRNPA1 is an abundant nuclear protein that plays an important role in pre-mRNA processing and mRNA export from the nucleus. A1 shuttles rapidly between the nucleus and the cytoplasm, and a 38-amino acid domain, M9, serves as the bi-directional transport signal of A1. Recently, a 90-kD protein, transportin, was identified as the mediator of A1 nuclear import. Transportin mediates the nuclear import of additional hnRNP proteins, including hnRNPF. The nuclear localization of A1 is dependent on ongoing RNA polymerase II transcription.

Database

Research Area

REFERENCE

Application Reference

Filatova A et al. Traffic 2009; 10 (11) : 1599-618 Novel shuttling domain in a regulator (RSC1A1) of transporter SGLT1 steers cell cycle-dependent nuclear location.
Application : WB
Reactivity : Mouse
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399