GeneTex
United States (US)

Troponin I skeletal muscle antibody [12F10]

Cat No. GTX28293

Host Mouse
Clonality Monoclonal
Clone Name 12F10
Isotype IgG2b
Application WB, Apuri, IA
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
Apuri Assay dependent
IA Assay dependent
Not tested in other applications.

Calculated MW

21.34 kDa. ( Note )

Specificity/Sensitivity

Cross-reaction with cardiac TnI is less than 0.05%.
PROPERTIES

Form

Liquid

Buffer

PBS pH 7.4, 0.09 % sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4º C.

Concentration

Batch dependent(Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human skTnI

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

AMCD2B, DA2B, FSSV, TNNI2, fsTnI, troponin I2, fast skeletal type, Troponin I fast skeletal muscle, fast skeletal muscle Troponin I

Background

This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

Database

Package List Price ($)
$ 199