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Twinkle antibody

Anti-Twinkle antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX53922
Anti-Twinkle antibody used in Western Blot (WB). GTX53922

Cat No. GTX53922

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, ICC/IF

Reactivity

Human
Package
100 μl ($319)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500-1:2000
ICC/IF 1:50-1:200
Not tested in other applications.

Calculated MW

77 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS pH7.3, 0.02% sodium azide, 50% glycerol.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 385-684 of human C10orf2 (NP_068602.2).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

twinkle mtDNA helicase , ATXN8 , C10orf2 , IOSCA , MTDPS7 , PEO , PEO1 , PEOA3 , PRLTS5 , SANDO , SCA8 , TWINL

Background

This gene encodes a hexameric DNA helicase which unwinds short stretches of double-stranded DNA in the 5' to 3' direction and, along with mitochondrial single-stranded DNA binding protein and mtDNA polymerase gamma, is thought to play a key role in mtDNA replication. The protein localizes to the mitochondrial matrix and mitochondrial nucleoids. Mutations in this gene cause infantile onset spinocerebellar ataxia (IOSCA) and progressive external ophthalmoplegia (PEO) and are also associated with several mitochondrial depletion syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Aug 2009]

Database

Research Area

DATA IMAGES

Anti-Twinkle antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX53922

GTX53922 ICC/IF Image

ICC/IF analysis of A549 cells using GTX53922 Twinkle antibody.
Blue : DAPI

Anti-Twinkle antibody used in Western Blot (WB). GTX53922

GTX53922 WB Image

WB analysis of MCF7 cell lysate using GTX53922 Twinkle antibody. The signal was developed with ECL plus-Enhanced.
Loading : 25ug per lane
Dilution : 1:1000

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf