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Tyrosinase antibody [T311]

Anti-Tyrosinase antibody [T311] used in IHC (Paraffin sections) (IHC-P). GTX20738

Cat. No. GTX20738

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 T311

Isotype

 IgG2a

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($459)
See all Tyrosinase products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:50‐1:100

Note :

IHC-P
Recommendations for antigen retrieval : EDTA buffer pH 8.0 at room temperature for 30 mins.
Not tested in other applications.

Calculated MW

60 kDa. ( Note )

Product Note

This antibody is specific to a cluster of proteins between 70-80 kDa known as tyrosinase. This antibody does not show any cross-reaction with MAGE-1 and tyrosinase-related protein-1, TRP-1/gp75. Staining of melanomas with this antibody showed tyrosinase in melanotic as well as amelanotic variants.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

BALB/C mice were injected with a recombinant tyrosinase protein.

Purification

Purified IgG

Conjugation

Unconjugated

RRID

AB_384413

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

tyrosinase , ATN , CMM8 , OCA1 , OCA1A , OCAIA , SHEP3

Background

The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008]

Database

Research Area

DATA IMAGES

Anti-Tyrosinase antibody [T311] used in IHC (Paraffin sections) (IHC-P). GTX20738

GTX20738 IHC-P Image

IHC-P analysis of human melanoma tissue using GTX20738 Tyrosinase antibody [T311].

REFERENCE

Application Reference

Ordonez NG et al. Hum Pathol 2014; 45 (2) : 191-205 Value of melanocytic-associated immunohistochemical markers in the diagnosis of malignant melanoma: a review and update.
Application : IHC-P
Reactivity : Human
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 459