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Tyrosine Hydroxylase antibody [185]

Orthogonal
Anti-Tyrosine Hydroxylase antibody [185] used in Immunohistochemistry (IHC). GTX10372
Anti-Tyrosine Hydroxylase antibody [185] used in Immunohistochemistry (IHC). GTX10372
Anti-Tyrosine Hydroxylase antibody [185] used in IHC (Paraffin sections) (IHC-P). GTX10372
Anti-Tyrosine Hydroxylase antibody [185] used in IHC (Frozen sections) (IHC-Fr). GTX10372

Cat. No. GTX10372

Reference 6

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 185

Isotype

 IgG2a

Application

 WB, ICC/IF, IHC-P, IHC-Fr, IHC

Reactivity

 Human, Mouse, Rat
Package
50 μl ($399)
See all Tyrosine Hydroxylase products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:25-1:50
ICC/IF Assay dependent
IHC-P Assay dependent
IHC-Fr Assay dependent
IHC Assay dependent
Not tested in other applications.

Calculated MW

56 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatnat

Preservative

15mM Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Mouse

Immunogen

Recombinant protein, C-terminal portion of mouse sequence

Purification

Unpurified

Conjugation

Unconjugated

RRID

AB_373127

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

tyrosine hydroxylase

Background

The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Tyrosine Hydroxylase antibody [185] used in Immunohistochemistry (IHC). GTX10372

GTX10372 IHC Image

IHC analysis of human heart tissue (labeling of intrinsic cardiac adrenergic (ICA) cells) using GTX10372 Tyrosine Hydroxylase antibody [185].

Anti-Tyrosine Hydroxylase antibody [185] used in Immunohistochemistry (IHC). GTX10372

GTX10372 IHC Image

IHC analysis of locus coeruleus using GTX10372 Tyrosine Hydroxylase antibody [185].

Anti-Tyrosine Hydroxylase antibody [185] used in IHC (Paraffin sections) (IHC-P). GTX10372

GTX10372 IHC-P Image

IHC-P analysis of human mid-brain tissue using GTX10372 Tyrosine Hydroxylase antibody [185].

Anti-Tyrosine Hydroxylase antibody [185] used in IHC (Frozen sections) (IHC-Fr). GTX10372

GTX10372 IHC-Fr Image

The data was published in the journal Front Neuroanat in 2017. PMID: 28775681

REFERENCE

Application Reference

Lin Z et al. Aging Cell 2023; 22 (10) : e13958 Inhibition of abnormal C/EBPβ/α-Syn signaling pathway through activation of Nrf2 ameliorates Parkinson's disease-like pathology.
Cao Q et al. Mol Ther Nucleic Acids 2022; 29 : 44941 Suppression of abnormal α-synuclein expression by activation of BDNF transcription ameliorates Parkinson's disease-like pathology.
Application : WB, ICC/IF
Reactivity : Mouse
Plummer NW et al. Front Neuroanat 2017; 11 : 60 Two Subpopulations of Noradrenergic Neurons in the Locus Coeruleus Complex Distinguished by Expression of the Dorsal Neural Tube Marker Pax7.
Application : IHC-Fr
Reactivity : Mouse
Chen C et al. Biochim Biophys Acta 2017; 1864 (10) : 1900-1912 Critical role of TRPC1 in thyroid hormone-dependent dopaminergic neuron development.
Application : ICC/IF
Reactivity : Mouse
Robertson SD et al. Brain Res 2016; 1641 (Pt B) : 234-44 Uncovering diversity in the development of central noradrenergic neurons and their efferents.
Application : IHC-Fr
Reactivity : Mouse
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SDS
Sodium Azide.pdf
Package List Price ($)
$ 399