GeneTex
United States (US)

UACA antibody [UACA/1222]

GTX35156_20170712_WB_18121410_143.jpg

Cat No. GTX35156

Host Mouse
Clonality Monoclonal
Clone Name UACA/1222
Isotype IgG1
Application WB
Reactivity Human, Mouse
APPLICATION

Application Note

WB:0.5-1ug/ml.

Calculated MW

163 kDa. ( Note )

Specificity/Sensitivity

UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.
PROPERTIES

Form

Liquid

Buffer

Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant human UACA protein

Purification

Ab purified from Bioreactor Concentrate by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Uveal Autoantigen With Coiled-Coil Domains And Ankyrin Repeats,Nucling,Uaca

Database

Research Area

DATA IMAGES
GTX35156_20170712_WB_18121410_143.jpg

GTX35156 WB Image

Western Blot of A549 Cell Lysate using UACA / Nucling Monoclonal Antibody (UACA/1222)

Package List Price ($)
$ 329