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UGT1A antibody

Anti-UGT1A antibody used in IHC (Paraffin sections) (IHC-P). GTX55835
Anti-UGT1A antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX55835
Anti-UGT1A antibody used in IHC (Paraffin sections) (IHC-P). GTX55835
Anti-UGT1A antibody used in IHC (Paraffin sections) (IHC-P). GTX55835
Anti-UGT1A antibody used in IHC (Paraffin sections) (IHC-P). GTX55835
Anti-UGT1A antibody used in Western Blot (WB). GTX55835

Cat No. GTX55835

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P

Reactivity

 Human, Mouse, Rat
Package
100 μl ($339)
See all UGT1A products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:2000
ICC/IF 1:50 - 1:200
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

60 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS pH7.3, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human UGT1A1 (NP_000454.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

UDP glucuronosyltransferase family 1 member A1 , BILIQTL1 , GNT1 , HUG-BR1 , UDPGT , UDPGT 1-1 , UGT1 , UGT1A

Cellular Localization

Endoplasmic reticulum membrane,Endoplasmic reticulum

Background

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-UGT1A antibody used in IHC (Paraffin sections) (IHC-P). GTX55835

GTX55835 IHC-P Image

IHC-P analysis of human liver cancer tissue using GTX55835 UGT1A antibody.
Blue : DAPI
Dilution : 1:100

Anti-UGT1A antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX55835

GTX55835 ICC/IF Image

ICC/IF analysis of U2OS cells using GTX55835 UGT1A antibody.
Blue : DAPI

Anti-UGT1A antibody used in IHC (Paraffin sections) (IHC-P). GTX55835

GTX55835 IHC-P Image

IHC-P analysis of mouse liver tissue using GTX55835 UGT1A antibody.
Blue : DAPI
Dilution : 1:100

Anti-UGT1A antibody used in IHC (Paraffin sections) (IHC-P). GTX55835

GTX55835 IHC-P Image

IHC-P analysis of rat liver tissue using GTX55835 UGT1A antibody.
Blue : DAPI
Dilution : 1:100

Anti-UGT1A antibody used in IHC (Paraffin sections) (IHC-P). GTX55835

GTX55835 IHC-P Image

IHC-P analysis of human liver cancer tissue using GTX55835 UGT1A antibody.
Dilution : 1:100

Anti-UGT1A antibody used in Western Blot (WB). GTX55835

GTX55835 WB Image

WB analysis of rat liver tissue lysate using GTX55835 UGT1A antibody.
Dilution : 1:1000
Loading : 25μg per lane

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 339