APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:500 - 1:2000 |
| 1:50 - 1:200 |
| 1:50 - 1:200 |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
PBS, 50% Glycerol
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human UGT1A1 (NP_000454.1).
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
UDP glucuronosyltransferase family 1 member A1 , BILIQTL1 , GNT1 , HUG-BR1 , UDPGT , UDPGT 1-1 , UGT1 , UGT1A
Cellular Localization
Endoplasmic reticulum membrane,Endoplasmic reticulum
Background
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX55835 IHC-P Image
IHC-P analysis of mouse liver tissue using GTX55835 UGT1A antibody.
Blue : DAPI
Dilution : 1:100
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GTX55835 ICC/IF Image
ICC/IF analysis of U2OS cells using GTX55835 UGT1A antibody.
Blue : DAPI
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GTX55835 IHC-P Image
IHC-P analysis of rat liver tissue using GTX55835 UGT1A antibody.
Blue : DAPI
Dilution : 1:100
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GTX55835 IHC-P Image
IHC-P analysis of human liver cancer tissue using GTX55835 UGT1A antibody.
Blue : DAPI
Dilution : 1:100
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GTX55835 WB Image
WB analysis of rat liver tissue lysate using GTX55835 UGT1A antibody.
Dilution : 1:1000
Loading : 25μg per lane
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GTX55835 IHC-P Image
IHC-P analysis of human liver cancer tissue using GTX55835 UGT1A antibody.
Dilution : 1:100
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REFERENCE
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REVIEW
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