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UHRF1 antibody

Anti-UHRF1 antibody used in IHC (Paraffin sections) (IHC-P). GTX32951
Anti-UHRF1 antibody used in Western Blot (WB). GTX32951
Anti-UHRF1 antibody used in IHC (Paraffin sections) (IHC-P). GTX32951
Anti-UHRF1 antibody used in IHC (Paraffin sections) (IHC-P). GTX32951
Anti-UHRF1 antibody used in IHC (Paraffin sections) (IHC-P). GTX32951
Anti-UHRF1 antibody used in IHC (Paraffin sections) (IHC-P). GTX32951
Anti-UHRF1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX32951

Cat No. GTX32951

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, ICC/IF, IHC-P

Reactivity

Human
Package
100 μl ($329)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:2000
ICC/IF 1:20 - 1:50
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

90 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS pH7.3, 0.02% sodium azide, 50% glycerol.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human UHRF1 (NP_001041666.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

ubiquitin like with PHD and ring finger domains 1 , ICBP90 , Np95 , RNF106 , TDRD22 , hNP95 , hUHRF1 , huNp95

Cellular Localization

Nucleus

Background

This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]

Database

Research Area

DATA IMAGES

Anti-UHRF1 antibody used in IHC (Paraffin sections) (IHC-P). GTX32951

GTX32951 IHC-P Image

IHC-P analysis of human colon carcinoma tissue using GTX32951 UHRF1 antibody.
Dilution : 1:100

Anti-UHRF1 antibody used in Western Blot (WB). GTX32951

GTX32951 WB Image

WB analysis of various samples using GTX32951 UHRF1 antibody.
Dilution : 1:1000
Loading : 25μg per lane

Anti-UHRF1 antibody used in IHC (Paraffin sections) (IHC-P). GTX32951

GTX32951 IHC-P Image

IHC-P analysis of human colon tissue using GTX32951 UHRF1 antibody.
Dilution : 1:100

Anti-UHRF1 antibody used in IHC (Paraffin sections) (IHC-P). GTX32951

GTX32951 IHC-P Image

IHC-P analysis of human lung cancer tissue using GTX32951 UHRF1 antibody.
Dilution : 1:100

Anti-UHRF1 antibody used in IHC (Paraffin sections) (IHC-P). GTX32951

GTX32951 IHC-P Image

IHC-P analysis of human gastric cancer tissue using GTX32951 UHRF1 antibody.
Dilution : 1:100

Anti-UHRF1 antibody used in IHC (Paraffin sections) (IHC-P). GTX32951

GTX32951 IHC-P Image

IHC-P analysis of human tonsil tissue using GTX32951 UHRF1 antibody.
Dilution : 1:100

Anti-UHRF1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX32951

GTX32951 ICC/IF Image

ICC/IF analysis of U2OS cell using GTX32951 UHRF1 antibody.
Blue : DAPI

REFERENCE

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REVIEW

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Package List Price ($)
$ 329