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UNG antibody

Anti-UNG antibody used in Western Blot (WB). GTX103236

Cat. No. GTX103236

Reference 2

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-Wm

Reactivity

 Human, Zebrafish
Package
100 μl ($399),
25 μl ($169)
See all UNG products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IHC-Wm Assay dependent
Not tested in other applications.

Calculated MW

35 kDa. ( Note )

Predict Reactivity

Mouse, Rat, Bovine, Chicken, Xenopus tropicalis, Chimpanzee(>80% identity)

PROPERTIES

Form

Liquid

Buffer

0.1M Tris, 0.1M Glycine, 10% Glycerol

Preservative

0.01% Thimerosal

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human UNG. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_1952519

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

uracil DNA glycosylase , DGU , HIGM4 , HIGM5 , UDG , UNG1 , UNG15 , UNG2

Cellular Localization

Isoform 1: Mitochondrion , Isoform 2: Nucleus

Background

This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. [provided by RefSeq]

Database

Research Area

DATA IMAGES

Anti-UNG antibody used in Western Blot (WB). GTX103236

GTX103236 WB Image

The data was published in the journal PLoS One in 2013.PMID: 24282540

REFERENCE

Application Reference

Wu D et al. J Biol Chem 2014; Uracil-DNA Glycosylase is involved in DNA demethylation and required for embryonic development in the zebrafish embryo.
Application : WB, IHC-Wm
Reactivity : Zebrafish
Lam T et al. PLoS One 2013; 8 (11) : e80414 Scaffold functions of 14-3-3 adaptors in B cell immunoglobulin class switch DNA recombination.
Application : WB
Reactivity : Human
Submit a Reference

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SDS
Glycerol.pdf
Thimerosal.pdf
Package List Price ($)
$ 399
$ 169