APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
0.5 - 1 μg/mL |
5 μg/mL |
Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
Human Kidney Tissue Lysate(GTX29995)
Product Note
At least two isoforms of UPK1B are known to exist; this antibody will recognize both isoforms. UPK1B antibody is predicted to not cross-react with other tetraspanin protein family members.
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
UPK1B antibody was raised against a 17 amino acid synthetic peptide near the center of human UPK1B.The immunogen is located within amino acids 110 - 160 of UPK1B.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
uroplakin 1B , TSPAN20 , UPIB , UPK1
Cellular Localization
Membrane; Multi-pass membrane protein
Background
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX32032 IHC-P Image
IHC-P analysis of human bladder tissue using GTX32032 UPK1B antibody. Working concentration : 20 μg/ml
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GTX32032 IHC-P Image
IHC-P analysis of human bladder tissue using GTX32032 UPK1B antibody. Working concentration : 5 μg/ml
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GTX32032 WB Image
WB analysis of human kidney tissue lysate in the (A) absence and (B) presence of blocking peptide using GTX32032 UPK1B antibody. Working concentration : 1 μg/ml
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REFERENCE
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REVIEW
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