GeneTex
United States (US)

URP2 antibody, C-term

GTX88332_2390_WB_18121411_606.jpg

Cat No. GTX88332

Host Goat
Clonality Polyclonal
Isotype IgG
Application WB
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1-3μg/ml
Not tested in other applications.

Calculated MW

76 kDa. ( Note )

Positive Control

The peptide used to generate this antibody is available for purchase (GTX88332-PEP).

Specificity/Sensitivity

This antibody is expected to recognize both isoforms (NP_113659.3, NP_848537.1).

Predict Reactivity

Mouse, Rat, Dog(>80% identity)
PROPERTIES

Form

Liquid

Buffer

Tris saline pH7.3, 0.02% sodium azide, 0.5% BSA.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.50mg/ml

Antigen Species

Human

Immunogen

Peptide with sequence C-ERARGEELDED, from the C Terminus of the protein sequence according to NP_113659.3; NP_848537.1.

Purification

Purified by ammonium sulphate precipitation followed by antigen affinity chromatography

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

UNC112C Antibody , URP2SF Antibody , MIG2B Antibody , FERMT3 Antibody , MIG2 Antibody , KIND3 Antibody

Cellular Localization

Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells.

Background

Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2010]
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Database

Research Area

DATA IMAGES
GTX88332_2390_WB_18121411_606.jpg

GTX88332 WB Image

WB analysis of human peripheral blood mononucleocytes lysate using GTX88332 URP2 antibody, C-term.
Dilution : 1µg/ml
Loading : 35µg protein in RIPA buffer