GeneTex
United States (US)

UVRAG antibody, C-term

GTX16333_653_IHC-P_18121410_684.jpg
GTX16333_552_ICC-IF_18121410_388.jpg

Cat No. GTX16333

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ICC/IF, IHC-P
Reactivity Human, Mouse
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:1000
ICC/IF 1:10-200
IHC-P 1:50-1:100
Not tested in other applications.

Calculated MW

78 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

PBS, 0.09% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

KLH conjugated synthetic peptide between 666-699 amino acids from the C-terminal region of human UVRAG.

Purification

Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Uv Radiation Resistance Associated,Dhtx,Vps38,P63,Uvrag

Background

This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES
GTX16333_653_IHC-P_18121410_684.jpg

GTX16333 IHC-P Image

IHC-P analysis of human hepatocarcinoma using GTX16333 UVRAG antibody, C-term.

GTX16333_552_ICC-IF_18121410_388.jpg

GTX16333 ICC/IF Image

ICC/IF analysis of U251 cells treated with Chloroquine (50 μM,16h) using GTX16333 UVRAG antibody, C-term.
Green : UVRAG
Blue : cell nuclear
Fixation : 4% paraformaldehyde (PFA) (20 min)
Permeabilization : Triton X-100 (0.2%, 30 min)
Dilution : 1:200

Package List Price ($)
$ 339