GeneTex
United States (US)

Ubinuclein 1 antibody

Ubinuclein-antibody-GTX87636-IHC-1_18122102_373.jpg
Ubinuclein-antibody-GTX87636-ICC_IF-1_18122102_962.jpg

Cat No. GTX87636

Host Rabbit
Clonality Polyclonal
Application ICC/IF, IHC-P, ELISA
Reactivity Human, Mouse
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
ICC/IF Assay dependent
IHC-P Assay dependent
ELISA Assay dependent
Not tested in other applications.

Calculated MW

121 kDa. ( Note )

Specificity/Sensitivity

Ubinuclein 1 Antibody detects endogenous levels of total Ubinuclein 1 protein.
PROPERTIES

Form

Liquid

Buffer

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Antigen Species

Human

Immunogen

The antiserum was produced against synthesized peptide derived from human Ubinuclein 1.

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

VT4, Ubiquitously expressed nuclear protein, Ubinuclein

Cellular Localization

Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When over

Background

Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly.
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Database

DATA IMAGES
Ubinuclein-antibody-GTX87636-IHC-1_18122102_373.jpg

GTX87636 IHC-P Image

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using Ubinuclein Antibody. The picture on the right is treated with the synthesized peptide.

Ubinuclein-antibody-GTX87636-ICC_IF-1_18122102_962.jpg

GTX87636 ICC/IF Image

Immunofluorescence analysis of A549 cells, using Ubinuclein Antibody. The picture on the right is treated with the synthesized peptide.

Package List Price ($)
$ 339