*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
Ubinuclein 1 Antibody detects endogenous levels of total Ubinuclein 1 protein.
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
The antiserum was produced against synthesized peptide derived from human Ubinuclein 1.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
VT4, Ubiquitously expressed nuclear protein, Ubinuclein
Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When over
Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly.
GTX87636 IHC-P Image
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using Ubinuclein Antibody. The picture on the right is treated with the synthesized peptide.
GTX87636 ICC/IF Image
Immunofluorescence analysis of A549 cells, using Ubinuclein Antibody. The picture on the right is treated with the synthesized peptide.