APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:2–1:10 |
|
Note :
IHC-Fr
Freeze specimen tissue blocks in isopentane chilled in liquid nitrogen.
|
Not tested in other applications.
Product Note
This antibody recognizes amino terminal domain of the human homolog of human dystrophin, utrophin.
PROPERTIES
Form
Liquid
Buffer
Tissue culture supernatant
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Antigen Species
Human
Immunogen
Fusion protein containing the first 261 amino acids of the published DMDL gene sequence.
Purification
Unpurified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
utrophin , DMDL , DRP , DRP1
Cellular Localization
Cytoplasm, cytoskeleton
Background
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
![Anti-Utrophin antibody [DRP3/20C5] used in IHC (Frozen sections) (IHC-Fr). GTX01977](/templates/default/js/lightbox/images/loading.gif "Anti-Utrophin antibody [DRP3/20C5] used in IHC (Frozen sections) (IHC-Fr). GTX01977")
|
GTX01977 IHC-Fr Image
IHC-Fr analysis of human skeletal muscle tissue using GTX01977 Utrophin antibody [DRP3/20C5].
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REFERENCE
There are currently no references for Utrophin antibody [DRP3/20C5] (GTX01977). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for Utrophin antibody [DRP3/20C5] (GTX01977). Be the first to share your experience with this product.
![Anti-Utrophin antibody [DRP3/20C5] used in IHC (Frozen sections) (IHC-Fr). GTX01977](/upload/website/prouct_img/small/GTX01977/GTX01977_20200811_IHC-Fr_4_w_23053121_495.webp "Anti-Utrophin antibody [DRP3/20C5] used in IHC (Frozen sections) (IHC-Fr). GTX01977")
![Anti-Utrophin antibody [DRP3/20C5] used in IHC (Frozen sections) (IHC-Fr). GTX01977](/upload/website/prouct_img/normal/GTX01977/GTX01977_20200811_IHC-Fr_4_w_23053121_495.webp "Anti-Utrophin antibody [DRP3/20C5] used in IHC (Frozen sections) (IHC-Fr). GTX01977")