GeneTex
  • Country / Location Selection

United States (US)

VEGF Receptor 2 antibody [6B11]

Anti-VEGF Receptor 2 antibody [6B11] used in Activation/Stimulation/Induction (Activation). GTX53462

Cat No. GTX53462

Host

Mouse

Clonality

Monoclonal

Clone Name

6B11

Isotype

IgG1

Application

WB, Activation, Neutralizing/Inhibition

Reactivity

Human
Package
100 μg ($379)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
Activation Assay dependent
Neutralizing/Inhibition Assay dependent

Note :


Attenuation of VEGF-induced VEGFR2 tyrosine phosphorylation

Not tested in other applications.

Calculated MW

152 kDa. ( Note )

Specificity/Sensitivity

This antibody recognizes hVEGFR-2 in western blot and it shows no cross-reactivity with hVEGFR-1.

PROPERTIES

Form

Liquid

Buffer

PBS

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

hVEGFR2 N-terminal fragment (N30-200)

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

CD309 , FLK1 , KDR , VEGFR , VEGFR2 , kinase insert domain receptor , VEGF Receptor 2

Cellular Localization

Cell membrane,Cytoplasm,Nucleus,Cytoplasmic vesicle,Early endosome,Cell junction,Secreted

Background

Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]

Database

Research Area

DATA IMAGES

Anti-VEGF Receptor 2 antibody [6B11] used in Activation/Stimulation/Induction (Activation). GTX53462

GTX53462 Activation Image

Activation assay analysis of HUVECs pre-treated with 5.0 and 25 μg/ml GTX53462 VEGF Receptor 2 antibody [6B11] and then stimulated with rhVEGF (10ng/ml) for 30min. The phospho-VEGFR2 was detected by detected with IP-Western for P-Tyrosine.

REFERENCE

REVIEW

There are currently no reviews for VEGF Receptor 2 antibody [6B11] (GTX53462). Be the first to share your experience with this product.
SDS
PBS.pdf