GeneTex
United States (US)

VEGF Receptor 2 antibody

GTX129943_41766_20161117_WB_18121410_173.jpg

Cat No. GTX129943

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500-1:3000
Not tested in other applications.

Calculated MW

152 kDa. ( Note )

Positive Control

HUVEC

Predict Reactivity

Mouse, Rat, Rabbit, Sheep, Bovine, Dog(>80% identity)
PROPERTIES

Form

Liquid

Buffer

1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1mg/ml(Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the C-terminus region of human VEGFR-2. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

FLK1 Antibody, kinase insert domain receptor (a type III receptor tyrosine kinase) Antibody, KDR Antibody, VEGFR2 Antibody, VEGFR Antibody, CD309 Antibody, VEGF Receptor 2

Cellular Localization

Membrane; Single-pass type I membrane protein

Background

Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq]

Database

Research Area

DATA IMAGES
GTX129943_41766_20161117_WB_18121410_173.jpg

GTX129943 WB Image

Whole cell extract (30 µg) was separated by 5% SDS-PAGE, and the membrane was blotted with VEGF Receptor 2 antibody (GTX129943) diluted at 1:500.

REFERENCE
SDS
PBS.pdf
Glycerol.pdf
Proclin.pdf