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VEGF Receptor 2 antibody

Cat. No. GTX17530

Reference 3

Host

 Chicken

Clonality

 Polyclonal

Isotype

 IgY

Application

 WB, IHC

Reactivity

 Human, Mouse, Rat, Bovine
Package
50 μg ($489)
See all VEGF Receptor 2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500
IHC 1:500
Not tested in other applications.

Calculated MW

152 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Immunogen Sequence: GI # 9087218, sequence 51-119 Recombinant vascular endothelial growth factor receptor 2

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

RRID

AB_422786

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

kinase insert domain receptor , CD309 , FLK1 , VEGFR , VEGFR2

Cellular Localization

Cell junction,Endoplasmic reticulum,Cytoplasm,Nucleus,Cytoplasmic vesicle

Background

VEGF receptor 2 is a member of a receptor tyrosine kinase family whose activation plays an essential role in a large number of biological processes such as embryonic development, wound healing, cell proliferation, migration and differentiation. Like other growth factor receptors, upon ligand binding VEGF receptor 2 dimerises and is autophosphorylated on multiple tyrosine residues. These sites can be involved in the regulation of kinase activity or serve as binding sites for SH2 and phosphotyrosine binding containing signalling proteins. Phosphorylation of Tyrosines 1054 and 1059 in the activation loop is required for activation of VEGF receptor 2 and its intrinsic tyrosine kinase activity.

Database

Research Area

REFERENCE

Application Reference

Davaatseren M et al. PLoS One 2014; 9 (7) : e102975 Allyl isothiocyanate ameliorates angiogenesis and inflammation in dextran sulfate sodium-induced acute colitis.
Application : WB
Reactivity : Mouse
Altshuler AE et al. Cell Mol Bioeng 2012; 5 (1) : 82-91 Proteolytic Activity Attenuates the Response of Endothelial Cells to Fluid Shear Stress.
Application : WB, IHC
Reactivity : Bovine
Alsaigh T et al. Microvasc Res 2011; 81 (1) : 108-16 Acute venous occlusion enhances matrix metalloprotease activity: Implications on endothelial dysfunction.
Application : IHC
Reactivity : Rat
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 489