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VEGF Receptor 2 antibody

Orthogonal
Anti-VEGF Receptor 2 antibody used in Activation/Stimulation/Induction (Activation). GTX52395

Cat. No. GTX52395

Host

 Goat

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IP, Activation

Reactivity

 Human
Package
50 μg ($689)
See all VEGF Receptor 2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IP Assay dependent
Activation Assay dependent

Note :

Activation
This antibody can induce hVEGFR2 phosphorylation in HUVECs at > 0.5 μg/mL.
Not tested in other applications.

Calculated MW

152 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

hVEGFR2 N-terminal fragment (N30-200)

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD309 , FLK1 , KDR , VEGFR , VEGFR2 , kinase insert domain receptor , VEGF Receptor 2

Cellular Localization

Cell membrane,Cytoplasm,Nucleus,Cytoplasmic vesicle,Early endosome,Cell junction,Secreted

Background

Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]

Database

Research Area

DATA IMAGES

Anti-VEGF Receptor 2 antibody used in Activation/Stimulation/Induction (Activation). GTX52395

GTX52395 Activation Image

Orthogonal

Activation assay analysis of HUVECs stimulated with 0.5, 1.0 and 2.0 μg/ml GTX52395 VEGF Receptor 2 antibody or 20ng/ml VEGF for 30mins. The phospho-VEGFR2 was detected with IP-Western for P-Tyrosine.

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 689