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VEGFA antibody [MAB0705]

Orthogonal
Anti-VEGFA antibody [MAB0705] used in Neutralizing/Blocking/Inhibition (Neutralizing/Inhibition). GTX53467

Cat. No. GTX53467

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 MAB0705

Isotype

 IgG1

Application

 WB, Neutralizing/Inhibition

Reactivity

 Human, Mouse
Package
100 μg ($689)
See all VEGFA products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
Neutralizing/Inhibition Assay dependent
Not tested in other applications.

Calculated MW

25 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

recombinant mouse VEGF

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Cellular Localization

Secreted,Cell membrane

Background

This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.[provided by RefSeq, Nov 2015]

Database

Research Area

DATA IMAGES

Anti-VEGFA antibody [MAB0705] used in Neutralizing/Blocking/Inhibition (Neutralizing/Inhibition). GTX53467

GTX53467 Neutralizing/Inhibition Image

Orthogonal

Neutralizing/Blocking assay analysis of mouse endothelial cells stimulated with mouse VEGFA for 20 mins in the absence or presence of GTX53467 VEGFA antibody [MAB0705]. The level of p-VEGFR2 was detected using anti-phospho-VEGF2.

REFERENCE

Clone Reference

V Kumar et al. Blood 2010; 115 (23):4725-33 Global lymphoid tissue remodeling during a viral infection is orchestrated by a B cell–lymphotoxin-dependent pathway
Application : Neutralizing/Inhibition
Reactivity : Mouse
Submit a Reference

REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 689