PRODUCT
Summary
This antibody was validated on 76 different Normal and cancerTissues by IHC-P.
APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:50-1:100 |
|
Note :
IHC-P
Manual staining : Heat-induced antigen retrieval for 5 minutes in an autoclave at 121ºC in pH 7.8 Tris-EDTA-based Target Retrieval Solution buffer.
|
Not tested in other applications.
Calculated MW
Positive Control
Colon: A moderate to strong endothelial vWF immunostaining should be seen in a fraction of blood vessels.
Negative Control
Colon: vWF immunostaining should be completely absent in epithelial and muscular cells.
PROPERTIES
Form
Liquid
Buffer
PBS, 0.05% BSA (Please contact us for PBS only format)
Preservative
0.05% sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant fragment of human vWF protein (aa1815-1939)
Purification
Protein A/G purified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
von Willebrand factor , F8VWF , VWD
Cellular Localization
Secreted , Secreted, extracellular space, extracellular matrix
Background
This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large multimeric complexes. These complexes function in the adhesion of platelets to sites of vascular injury and the transport of various proteins in the blood. Mutations in this gene result in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Oct 2015]
Database
Research Area
DATA IMAGES
![Anti-VWF antibody [MSVA-521R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04412](/templates/default/js/lightbox/images/loading.gif "Anti-VWF antibody [MSVA-521R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04412")
|
GTX04412 IHC-P Image
IHC-P analysis of human duodenum Brunner gland tissue section using GTX04412 VWF antibody [MSVA-521R] HistoMAX™.
In the Brunner gland endothelial, VWF immunostaining is strongest in venules.
|
|
|
GTX04412 IHC-P Image
IHC-P analysis of human ovary serous high grade carcinoma tissue section using GTX04412 VWF antibody [MSVA-521R] HistoMAX™.
Serous high grade carcinoma showing distinct endothelial VWF staining in a subset of intratumoral vessels.
|
|
|
GTX04412 IHC-P Image
IHC-P analysis of human skeletal muscle tissue section using GTX04412 VWF antibody [MSVA-521R] HistoMAX™.
In skeletal muscle endothelial VWF immunostaining is strong in postcapillary venules and somewhat weaker in capillaries.
|
REFERENCE
There are currently no references for VWF antibody [MSVA-521R] HistoMAX™ (GTX04412). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for VWF antibody [MSVA-521R] HistoMAX™ (GTX04412). Be the first to share your experience with this product.
![Anti-VWF antibody [MSVA-521R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04412](/upload/website/prouct_img/small/GTX04412/GTX04412_20230728_IHC-P_128_23072722_520.webp "Anti-VWF antibody [MSVA-521R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04412")
![Anti-VWF antibody [MSVA-521R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04412](/upload/website/prouct_img/small/GTX04412/GTX04412_20230728_IHC-P_258_23072723_302.webp "Anti-VWF antibody [MSVA-521R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04412")
![Anti-VWF antibody [MSVA-521R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04412](/upload/website/prouct_img/small/GTX04412/GTX04412_20230728_IHC-P_388_23072723_271.webp "Anti-VWF antibody [MSVA-521R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04412")
![Anti-VWF antibody [MSVA-521R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04412](/upload/website/prouct_img/normal/GTX04412/GTX04412_20230728_IHC-P_128_23072722_520.webp "Anti-VWF antibody [MSVA-521R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04412")
![Anti-VWF antibody [MSVA-521R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04412](/upload/website/prouct_img/normal/GTX04412/GTX04412_20230728_IHC-P_258_23072723_302.webp "Anti-VWF antibody [MSVA-521R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04412")
![Anti-VWF antibody [MSVA-521R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04412](/upload/website/prouct_img/normal/GTX04412/GTX04412_20230728_IHC-P_388_23072723_271.webp "Anti-VWF antibody [MSVA-521R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04412")