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Vitamin K epoxide reductase antibody

Anti-Vitamin K epoxide reductase antibody used in IHC (Paraffin sections) (IHC-P). GTX47837
Anti-Vitamin K epoxide reductase antibody used in Western Blot (WB). GTX47837
Anti-Vitamin K epoxide reductase antibody used in IHC (Paraffin sections) (IHC-P). GTX47837

Cat. No. GTX47837

Reference 3

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P, IP, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($449)
See all Vitamin K epoxide reductase products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500
ICC/IF 1:250
IHC-P Assay dependent
IP 1:200
ELISA 1:50000
Not tested in other applications.

Calculated MW

18 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Tris/Glycine, 0.5% BSA, 30% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.65-0.70 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide taken within amino acid region 10-60 on human VKORC1 protein.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

vitamin K epoxide reductase complex subunit 1 , EDTP308 , MST134 , MST576 , VKCFD2 , VKOR

Cellular Localization

Endoplasmic reticulum membrane

Background

This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane. Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotting enzymes. Allelic variation in this gene is associated with vitamin k-dependent clotting factors combined deficiency of 2, and increased resistance or sensitivity to warfarin, an inhibitor of vitamin K epoxide reductase. Pseudogenes of this gene are located on chromosomes 1 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Database

Research Area

DATA IMAGES

Anti-Vitamin K epoxide reductase antibody used in IHC (Paraffin sections) (IHC-P). GTX47837

GTX47837 IHC-P Image

IHC-P analysis of rat small intestine tissue using GTX47837 Vitamin K epoxide reductase antibody.
Dilution : 1:100

Anti-Vitamin K epoxide reductase antibody used in Western Blot (WB). GTX47837

GTX47837 WB Image

WB analysis of VKORC1 recombinant protein using GTX47837 Vitamin K epoxide reductase antibody.
Dilution : 1:500

Anti-Vitamin K epoxide reductase antibody used in IHC (Paraffin sections) (IHC-P). GTX47837

GTX47837 IHC-P Image

IHC-P analysis of rat liver tissue using GTX47837 Vitamin K epoxide reductase antibody.
Dilution : 1:100

REFERENCE

Application Reference

Xu J et al. Poult Sci 2023; 102 (3) : 102482 Sodium dehydroacetate-induced disorder of coagulation function in broiler chickens and the protective effect afforded by vitamin K.
Zhiqiang Zhou et al. Toxicol In Vitro . 2023; Mechanism of VKORC1 and VKORC1L1 signaling in the effects of sodium dehydroacetate on coagulation factors in rat hepatocytes
Application : WB
Reactivity : Rat
Xin Chen et al. Front Pharmacol 2021; 12 : 727084 Sex Metabolic Differences and Effects on Blood Coagulation Among Rats Exposed to Sodium Dehydroacetate.
Application : WB
Reactivity : Rat
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REVIEW

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Package List Price ($)
$ 449