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Von Hippel Lindau ELISA Pair

Von Hippel Lindau ELISA Pair. GTX500022

Cat No. GTX500022

Application

ELISA, Sandwich ELISA

Reactivity

Human
Package
1 pair ($399)
PRODUCT

Product Content

GTX101087
Type : Capture Antibody
Host : Rabbit
Conjugation : Unconjugated
Package : 50 μl
GTX89268
Type : Detection Antibody
Host : Goat
Conjugation : Unconjugated
Package : 50 μl

APPLICATION

Application Note

We recommend using the capture antibody at a concentration of 2.5μg/mL and the detection antibody at a concentration of 1.5μg/mL. Optimal dilutions should be determined experimentally by the researcher.

PROPERTIES

Form

Liquid

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC.  For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Von Hippel-Lindau Tumor Suppressor , Hrca1 , Rca1 , Vhl1 , Pvhl , Vhl

Background

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]

Research Area

DATA IMAGES

Von Hippel Lindau ELISA Pair. GTX500022

GTX500022 ELISA Image

ELISA detection of VHL using GTX101087 for capture at a concentration of 2.5 μg/mL and GTX89268 for detection at a concentration of 1.5 μg/mL. The HRP-conjugated anti-goat IgG antibody (GTX26741) was diluted at 1:20,000-1:200,000 and used to detect the primary antibody.

REFERENCE

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