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Von Hippel Lindau antibody [3F391]

Anti-Von Hippel Lindau antibody [3F391] used in Western Blot (WB). GTX11189

Cat. No. GTX11189

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 3F391

Isotype

 IgG1

Application

 WB, ELISA, IHC

Reactivity

 Human, Mouse
Package
250 μl ($399)
See all Von Hippel Lindau products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ELISA Assay dependent
IHC Assay dependent
Not tested in other applications.

Calculated MW

24 kDa. ( Note )

Product Note

Does not recognize the truncated form of VHL protein.

PROPERTIES

Form

Liquid

Buffer

PBS pH7.4, 0.2% BSA

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein containing aa1-213 of human Von Hippel-Lindau Protein (vHL). Epitope: aa1-54.

Purification

Protein G purified

Conjugation

Unconjugated

RRID

AB_381272

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

HRCA1 , RCA1 , VHL , VHL1 , pVHL , von HippelLindau tumor suppressor , Von Hippel Lindau , von Hippel-Lindau tumor suppressor

Cellular Localization

Cytoplasm,Membrane,Nucleus

Background

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Von Hippel Lindau antibody [3F391] used in Western Blot (WB). GTX11189

GTX11189 WB Image

WB analysis of mouse cell lysate using GTX11189 Von Hippel Lindau antibody [3F391].

REFERENCE

Application Reference

Jatta K et al. J Clin Pathol 2009; 62 (1) : 25720 Overexpression of von Hippel-Lindau protein in skeletal muscles of patients with chronic obstructive pulmonary disease.
Application : IHC
Reactivity : Human
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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399