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Von Hippel Lindau antibody

Anti-Von Hippel Lindau antibody used in IHC (Paraffin sections) (IHC-P). GTX32968
Anti-Von Hippel Lindau antibody used in Western Blot (WB). GTX32968
Anti-Von Hippel Lindau antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX32968
Anti-Von Hippel Lindau antibody used in IHC (Paraffin sections) (IHC-P). GTX32968
Anti-Von Hippel Lindau antibody used in IHC (Paraffin sections) (IHC-P). GTX32968

Cat. No. GTX32968

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399)
See all Von Hippel Lindau products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
ICC/IF 1:50 - 1:200
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

24 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-172 of human VHL (NP_937799.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

von Hippel-Lindau tumor suppressor , HRCA1 , RCA1 , VHL1 , pVHL

Cellular Localization

Nucleus

Background

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Von Hippel Lindau antibody used in IHC (Paraffin sections) (IHC-P). GTX32968

GTX32968 IHC-P Image

IHC-P analysis of rat ovary tissue using GTX32968 Von Hippel Lindau antibody.
Dilution : 1:200

Anti-Von Hippel Lindau antibody used in Western Blot (WB). GTX32968

GTX32968 WB Image

WB analysis of various sample lysates using GTX32968 Von Hippel Lindau antibody.
Dilution : 1:1000
Loading : 25μg per lane

Anti-Von Hippel Lindau antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX32968

GTX32968 ICC/IF Image

ICC/IF analysis of U-251 MG cells using GTX32968 Von Hippel Lindau antibody.
Blue : DAPI
Dilution : 1:100

Anti-Von Hippel Lindau antibody used in IHC (Paraffin sections) (IHC-P). GTX32968

GTX32968 IHC-P Image

IHC-P analysis of mouse spleen tissue using GTX32968 Von Hippel Lindau antibody.
Dilution : 1:200

Anti-Von Hippel Lindau antibody used in IHC (Paraffin sections) (IHC-P). GTX32968

GTX32968 IHC-P Image

IHC-P analysis of human tonsil tissue using GTX32968 Von Hippel Lindau antibody.
Dilution : 1:200

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399