GeneTex
United States (US)

WASP antibody

GTX16382_20180530_WB_18121410_650.jpg
GTX16382_20180530_ICCIF_18121410_711.jpg

Cat No. GTX16382

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ICC/IF
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:2000
ICC/IF Assay dependent
Not tested in other applications.

Calculated MW

53 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

PBS pH7.3, 0.02% sodium azide, 50% glycerol.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 60-250 of human WAS (NP_000368.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Wiskott-Aldrich Syndrome,Imd2,Scnx,Thc,Thc1,Wasp,Waspa,Was

Background

The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a dif

Database

DATA IMAGES
GTX16382_20180530_WB_18121410_650.jpg

GTX16382 WB Image

WB analysis of various samples using GTX16382 WASP antibody.
Dilution : 1:1000
Loading : 25μg per lane

GTX16382_20180530_ICCIF_18121410_711.jpg

GTX16382 ICC/IF Image

ICC/IF analysis of U2OS cell using GTX16382 WASP antibody.
Blue : DAPI

Package List Price ($)
$ 319