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WRN antibody [HL1729]

Recombinant antibody
Anti-WRN antibody [HL1729] used in IHC (Paraffin sections) (IHC-P). GTX637377
Anti-WRN antibody [HL1729] used in Western Blot (WB). GTX637377

Cat. No. GTX637377

Host

 Rabbit

Clonality

 Monoclonal

Clone Name

 HL1729

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human
Package
100 μl ($399),
25 μl ($169)
See all WRN products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:3000
IHC-P Assay dependent
Not tested in other applications.

Calculated MW

162 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human WRN. The exact sequence is proprietary.

Purification

Affinity purified by Protein A.

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

Werner syndrome RecQ like helicase , RECQ3 , RECQL2 , RECQL3

Cellular Localization

Nucleus,nucleoplasm,Nucleolus

Background

This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]

Database

Research Area

DATA IMAGES

Anti-WRN antibody [HL1729] used in IHC (Paraffin sections) (IHC-P). GTX637377

GTX637377 IHC-P Image

WRN antibody [HL1729] detects WRN protein at nucleus by immunohistochemical analysis.
Sample: Paraffin-embedded human breast carcinoma.
WRN stained by WRN antibody [HL1729] (GTX637377) diluted at 1:100.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-WRN antibody [HL1729] used in Western Blot (WB). GTX637377

GTX637377 WB Image

Various whole cell extracts (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with WRN antibody [HL1729] (GTX637377) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

REFERENCE

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REVIEW

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Package List Price ($)
$ 399
$ 169
Custom Conjugations