GeneTex
United States (US)

WWOX2 antibody

Cat No. GTX14937

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application Dot, ELISA
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

Dot: Use at a dilution of 1/10000 - 1/100000. ELISA: Use at a dilution of 1/10000 - 1/100000. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

47 kDa. ( Note )
PROPERTIES

Form

Liquid

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide.

Purification

Immunogen affinity purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Ww Domain Containing Oxidoreductase,D16S432E,Eiee28,For,Fra16D,Hhcma56,Pro0128,Scar12,Sdr41C1,Wox1,Wwox

Background

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates 7 transcript variants, which encode different isoforms.

Database

Research Area