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Wilms Tumor 1 antibody [6F-H2] (ready-to-use)

Anti-Wilms Tumor 1 antibody [6F-H2] (ready-to-use) used in IHC (Paraffin sections) (IHC-P). GTX04961

Cat. No. GTX04961

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 6F-H2

Isotype

 IgG1

Application

 IHC-P

Reactivity

 Human, Mouse, Rat, Dog
Package
6 ml ($499)
See all Wilms Tumor 1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P Assay dependent

Note :

IHC-P
Recommendations for antigen retrieval : EDTA Buffer pH 8.0
Not tested in other applications.

PROPERTIES

Form

Liquid

Buffer

Batch dependent

Preservative

0.09% Sodium Azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein corresponding to residues 1-181 of human WT1.

Purification

Protein G Purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

AWT1,EWSWT1,GUD,NPHS4,WAGR,WIT2,WT1,WT33,Wilms tumor 1,Wilms Tumor 1,WT1 transcription factor

Cellular Localization

Nucleus,Nucleolus,Cytoplasm,Nucleus speckle,Nucleoplasm

Background

This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]

Database

Research Area

DATA IMAGES

Anti-Wilms Tumor 1 antibody [6F-H2] (ready-to-use) used in IHC (Paraffin sections) (IHC-P). GTX04961

GTX04961 IHC-P Image

IHC-P analysis of human Wilm’s Tumor tissue using GTX04961 Wilms Tumor 1 antibody [6F-H2] (ready-to-use).
Antigen retrieval : EDTA Buffer pH 8.0.

REFERENCE

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REVIEW

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Package List Price ($)
$ 499