GeneTex
United States (US)

XIAP antibody

KO/KD
GTX33586_20180822_WB_18121410_117.jpg
GTX33586_20180530_IHC-P_1_18121410_799.jpg
GTX33586_20180530_WB_18121410_433.jpg
GTX33586_20180530_IHC-P_18121410_872.jpg

Cat No. GTX33586

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:2000
IHC-P 1:50 - 1:100
Not tested in other applications.

Calculated MW

57 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

PBS pH7.3, 0.02% sodium azide, 50% glycerol.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human XIAP (NP_001158.2).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

X-Linked Inhibitor Of Apoptosis,Api3,Birc4,Iap-3,Ilp1,Miha,Xlp2,Hiap-3,Hiap3,Xiap

Background

This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]

Database

Research Area

DATA IMAGES
GTX33586_20180822_WB_18121410_117.jpg

GTX33586 WB Image

KO/KD

WB analysis of wild type and XIAP knockout cell lysate using GTX33586 XIAP antibody.
Dilution : 1:1000
Loading : 25μg per lane

GTX33586_20180530_IHC-P_1_18121410_799.jpg

GTX33586 IHC-P Image

IHC-P analysis of mouse kidney tissue using GTX33586 XIAP antibody.
Dilution : 1:100

GTX33586_20180530_WB_18121410_433.jpg

GTX33586 WB Image

WB analysis of various samples using GTX33586 XIAP antibody.
Dilution : 1:1000
Loading : 25μg per lane

GTX33586_20180530_IHC-P_18121410_872.jpg

GTX33586 IHC-P Image

IHC-P analysis of human kidney tissue using GTX33586 XIAP antibody.
Dilution : 1:100

Package List Price ($)
$ 329