APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:500 - 1:2000 |
| 1:50 - 1:100 |
| 1:50 - 1:100 |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
PBS, 50% Glycerol
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human XIAP (NP_001158.2).
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
X-linked inhibitor of apoptosis , API3 , BIRC4 , IAP-3 , ILP1 , MIHA , XLP2 , hIAP-3 , hIAP3
Cellular Localization
Cytoplasm,Nucleus
Background
This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]
Database
Research Area
DATA IMAGES
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GTX33586 WB Image
WB analysis of various sample lysates using GTX33586 XIAP antibody.
Dilution : 1:1000
Loading : 25μg per lane
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GTX33586 ICC/IF Image
ICC/IF analysis of MCF7 cells using GTX33586 XIAP antibody.
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GTX33586 IHC-P Image
IHC-P analysis of human kidney tissue using GTX33586 XIAP antibody.
Dilution : 1:100
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GTX33586 IHC-P Image
IHC-P analysis of mouse kidney tissue using GTX33586 XIAP antibody.
Dilution : 1:100
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GTX33586 WB Image
WB analysis of normal (control) and knockout (KO) HeLa cell lysate using GTX33586 XIAP antibody.
Dilution : 1:1000
Loading : 25μg per lane
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REFERENCE
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REVIEW
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