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United States (US)

XPG antibody

Cat. No. GTX20046

Host

 Mouse

Clonality

 Monoclonal

Isotype

 IgG2a

Application

 WB, IP

Reactivity

 Human
Package
100 μg ($399)
See all XPG products

APPLICATION

Application Note

Suggested working dilutions: Western blot: 1:625-1:1250, immunoprecipitation: 2 μg/mg protein lysate.

Calculated MW

133 kDa. ( Note )

Product Note

Epitope: 8H7 binds between human XPG residues Ser 947 and Ala 1165.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human XPG (Xeroderma Pigmentosum type G) protein produced in Baculovirus.

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ERCC excision repair 5, endonuclease , COFS3 , ERCC5-201 , ERCM2 , UVDR , XPG , XPGC

Cellular Localization

Nucleus

Background

This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, cognitive disability, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene. [provided by RefSeq, Feb 2011]

Database

Research Area

REFERENCE

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REVIEW

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Package List Price ($)
$ 399
Custom Conjugations