ELISA: Use at a dilution of 1/15,000 - 1/20,000. WB: Use at an assay dependent dilution. Predicted molecular weight: 13.8 kDa. Optimal dilutions/concentrations should be determined by the end user.
These antibodies have been fully characterized for cross-reactivity with other members of the amplicon related proteins.
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
0.5 mg/ml (Please refer to the vial label for the specific concentration.)
Synthetic peptide: EPGQTSVAPPPEEVEPGSC, corresponding to N terminal amino acids 4-21 of Human XTP4.
Immunogen affinity purified
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Migration And Invasion Enhancer 1,C17Orf37,C35,Orb3,Rdx12,Xtp4,Mien1
Certain loci on human chromosome 17q12 are frequently amplified in various types of cancers. One of such loci is PP1R1B-ERBB2-GRB7 which is greatly amplified in gastric and breast cancer. Search of other genes that reside close to this recombination hot spot or ""fragile loci"" led to discovery of several genes, one of these genes is a new theoretical protein MGC14832 is localized on chromosome 17 at cytogenetic location of 17q21.2. The detailed analyses of the amplicon structure in 330 breast tumors samples revealed a 280 kb common region of amplification that contains 10 genes that include 8 known genes. A highly significant association between amplification and expression levels was observed for 6 genes including ERBB2 and 2 uncharacterized hypothetical proteins, MGC9753 and MGC14832, in breast carcinoma and human gastric cancer samples. MGC14832 is located on human chromosome 17q12 and is in the amplicon cluster consist of PPP1R1B-STARD3-TCAP-PNMT-MGC9753-ERBB2-MGC14832-GRB7 with in the 120 kb region locus on human chromosome 17q12.