GeneTex

  • Country / Location Selection

United States (US)

ZAP70 antibody [L453R]

Anti-ZAP70 antibody [L453R] used in IHC (Paraffin sections) (IHC-P). GTX01960

Cat. No. GTX01960

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 L453R

Isotype

 IgG2b

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($969)
See all ZAP70 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:100

Note :

IHC-P
The recommended fixative is 10% neutral-buffered formalin for paraffin-embedded tissue sections. Heat Induced Epitope Retreival (HIER) was performed in Epitope Retreival Solution pH6.
Not tested in other applications.

Calculated MW

70 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant, dialyzed and diluted in PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Antigen Species

Human

Immunogen

A prokaryotic recombinant protein corresponding to a portion of the N-terminus.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

zeta chain of T cell receptor associated protein kinase 70 , ADMIO2 , IMD48 , SRK , STCD , STD , TZK , ZAP-70

Cellular Localization

Cytoplasm , Cell membrane

Background

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-ZAP70 antibody [L453R] used in IHC (Paraffin sections) (IHC-P). GTX01960

GTX01960 IHC-P Image

IHC-P analysis of human B cell chronic lymphocytic leukemia tissue using GTX01960 ZAP70 antibody [L453R]. Note staining of malignant lymphocytic leukemic cells and intense staining of infiltrating T lymphocytes.

REFERENCE

There are currently no references for ZAP70 antibody [L453R] (GTX01960). Be the first to share your publications with this product.
Submit a Reference

REVIEW

There are currently no reviews for ZAP70 antibody [L453R] (GTX01960). Be the first to share your experience with this product.
Submit a Review
Package List Price ($)
$ 969