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ZAP70 antibody [ZAP70/3921R]

Anti-ZAP70 antibody [ZAP70/3921R] used in IHC (Paraffin sections) (IHC-P). GTX02745
Anti-ZAP70 antibody [ZAP70/3921R] used in IHC (Paraffin sections) (IHC-P). GTX02745
Anti-ZAP70 antibody [ZAP70/3921R] used in IHC (Paraffin sections) (IHC-P). GTX02745

Cat. No. GTX02745

Host

 Rabbit

Clonality

 Monoclonal

Clone Name

 ZAP70/3921R

Isotype

 IgG

Application

 IHC-P, ELISA

Reactivity

 Human
Package
100 μg ($529)
See all ZAP70 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1-2 μg/ml
ELISA 2-4 μg/ml (for coating)

Note :

IHC-P
Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris buffer with 1mM EDTA (pH 9.0) for 45 min at 95ºC followed by cooling at RT for 20 minutes.

ELISA
For ELISA coating, recommend using BSA-free format (please contact us for PBS only format).
Not tested in other applications.

Calculated MW

70 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

1mM PBS, 0.05% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

200 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fragment (around aa 247-382) ofhuman ZAP70 protein

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

zeta chain of T cell receptor associated protein kinase 70 , ADMIO2 , IMD48 , SRK , STCD , STD , TZK , ZAP-70

Cellular Localization

Cytoplasm , Cell membrane

Background

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-ZAP70 antibody [ZAP70/3921R] used in IHC (Paraffin sections) (IHC-P). GTX02745

GTX02745 IHC-P Image

IHC-P analysis of human lymphoma section using GTX02745 ZAP70 antibody [ZAP70/3921R].

Anti-ZAP70 antibody [ZAP70/3921R] used in IHC (Paraffin sections) (IHC-P). GTX02745

GTX02745 IHC-P Image

IHC-P analysis of human lymphoma section using GTX02745 ZAP70 antibody [ZAP70/3921R].

Anti-ZAP70 antibody [ZAP70/3921R] used in IHC (Paraffin sections) (IHC-P). GTX02745

GTX02745 IHC-P Image

IHC-P analysis of human tonsil tissue section using GTX02745 ZAP70 antibody [ZAP70/3921R].

REFERENCE

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REVIEW

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Package List Price ($)
$ 529