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ZAP70 antibody [ZAP70/4040R]

Anti-ZAP70 antibody [ZAP70/4040R] used in IHC (Paraffin sections) (IHC-P). GTX02746
Anti-ZAP70 antibody [ZAP70/4040R] used in IHC (Paraffin sections) (IHC-P). GTX02746

Cat No. GTX02746

Host

Rabbit

Clonality

Monoclonal

Clone Name

ZAP70/4040R

Isotype

IgG

Application

IHC-P, ELISA

Reactivity

Human
Package
100 μg ($429)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P 1-2 μg/ml
ELISA 2-4 μg/ml (for coating)

Note :

IHC-P
Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris buffer with 1mM EDTA (pH 9.0) for 45 min at 95ºC followed by cooling at RT for 20 minutes.

ELISA
For ELISA coating, recommend using BSA-free format (please contact us for PBS only format).

Not tested in other applications.

Calculated MW

70 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

1mM PBS, 0.05% BSA, 0.05% azide (Please contact us for PBS only format)

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

200 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide corresponding to human ZAP-70 residues within aa200-350

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

zeta chain of T cell receptor associated protein kinase 70 , ADMIO2 , IMD48 , SRK , STCD , STD , TZK , ZAP-70

Cellular Localization

Cytoplasm , Cell membrane

Background

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-ZAP70 antibody [ZAP70/4040R] used in IHC (Paraffin sections) (IHC-P). GTX02746

GTX02746 IHC-P Image

IHC-P analysis of human tonsil tissue section using GTX02746 ZAP70 antibody [ZAP70/4040R].

Anti-ZAP70 antibody [ZAP70/4040R] used in IHC (Paraffin sections) (IHC-P). GTX02746

GTX02746 IHC-P Image

IHC-P analysis of human tonsil tissue section using GTX02746 ZAP70 antibody [ZAP70/4040R].

REFERENCE

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REVIEW

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Package List Price ($)
$ 429