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alpha 1 Spectrin antibody [SPTA1/2939R]

Anti-alpha 1 Spectrin antibody [SPTA1/2939R] used in IHC (Paraffin sections) (IHC-P). GTX02715
Anti-alpha 1 Spectrin antibody [SPTA1/2939R] used in IHC (Paraffin sections) (IHC-P). GTX02715
Anti-alpha 1 Spectrin antibody [SPTA1/2939R] used in Western Blot (WB). GTX02715

Cat No. GTX02715

Host

Rabbit

Clonality

Monoclonal

Clone Name

SPTA1/2939R

Isotype

IgG

Application

WB, IHC-P, ELISA

Reactivity

Human
Package
100 μg ($429)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1-2 μg/ml
IHC-P 1-2 μg/ml
ELISA 2-4 μg/ml (for coating)

Note :

IHC-P
Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris buffer with 1mM EDTA (pH 9.0) for 45 min at 95ºC followed by cooling at RT for 20 minutes.

ELISA
For ELISA coating, recommend using BSA-free format (please contact us for PBS only format).

Not tested in other applications.

Calculated MW

280 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA, 0.05% azide (Please contact us for PBS only format)

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

200 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fragment of human SPTA (around aa356-475)

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

spectrin alpha, erythrocytic 1 , EL2 , HPP , HS3 , SPH3 , SPTA

Cellular Localization

Cytoplasm, cytoskeleton

Background

This gene encodes a member of a family of molecular scaffold proteins that link the plasma membrane to the actin cytoskeleton and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms a component of the erythrocyte plasma membrane. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis-2, pyropoikilocytosis, and spherocytosis, type 3. [provided by RefSeq, Aug 2017]

Database

Research Area

DATA IMAGES

Anti-alpha 1 Spectrin antibody [SPTA1/2939R] used in IHC (Paraffin sections) (IHC-P). GTX02715

GTX02715 IHC-P Image

IHC-P analysis of human pancreas tissue section using GTX02715 alpha 1 Spectrin antibody [SPTA1/2939R].

Anti-alpha 1 Spectrin antibody [SPTA1/2939R] used in IHC (Paraffin sections) (IHC-P). GTX02715

GTX02715 IHC-P Image

IHC-P analysis of human pancreas tissue section using GTX02715 alpha 1 Spectrin antibody [SPTA1/2939R].

Anti-alpha 1 Spectrin antibody [SPTA1/2939R] used in Western Blot (WB). GTX02715

GTX02715 WB Image

WB analysis of K562 whole cell lysate using GTX02715 alpha 1 Spectrin antibody [SPTA1/2939R].

REFERENCE

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REVIEW

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