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alpha Synuclein antibody [5C2]

Anti-alpha Synuclein antibody [5C2] used in Western Blot (WB). GTX57554

Cat. No. GTX57554

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 5C2

Isotype

 IgG1

Application

 WB

Reactivity

 Human
Package
100 μl ($399)
See all alpha Synuclein products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:2000
Not tested in other applications.

Calculated MW

14 kDa. ( Note )

Product Note

Based on internal testing result, this antibody does not cross react with human beta- and gamma-synuclein.This antibody specifically recognizes the NAC domain (61-95aa) of alpha-synuclein.

PROPERTIES

Form

Liquid

Buffer

PBS, 10% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The clone 5C2 is derived from hybridization of mouse SP2/2 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human alpha-synuclein protein.

Purification

Protein G Purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

synuclein alpha , NACP , PARK1 , PARK4 , PD1 , SNCA , alpha Synuclein

Cellular Localization

Cytoplasm,Cytosol,Membrane,Nucleus,Cell junction,Synapse,Secreted

Background

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]

Database

Research Area

DATA IMAGES

Anti-alpha Synuclein antibody [5C2] used in Western Blot (WB). GTX57554

GTX57554 WB Image

WB analysis of various samples using GTX57554 alpha Synuclein antibody.
Samples : Recombinant Human protein of synuclein family (alpha-, beta- and gamma-) and alpha-synuclein domains (1-60, 1-95, 61-140 and 96-140)
Dilution : 1:1000

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399