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alpha Synuclein antibody [AT1E10]

Anti-alpha Synuclein antibody [AT1E10] used in Western Blot (WB). GTX57587
Anti-alpha Synuclein antibody [AT1E10] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX57587
Anti-alpha Synuclein antibody [AT1E10] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX57587

Cat. No. GTX57587

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 AT1E10

Isotype

 IgG1

Application

 WB, ICC/IF

Reactivity

 Human
Package
100 μl ($399)
See all alpha Synuclein products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Recommended starting dilution is 1:500.
ICC/IF Assay dependent
Not tested in other applications.

Calculated MW

14 kDa. ( Note )

Product Note

Based on internal testing result, this antibody does not cross react with human beta- and gamma-synuclein protein.

PROPERTIES

Form

Liquid

Buffer

PBS, 10% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The clone AT1E10 is derived from hybridization of mouse F2 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human alpha-synuclein protein.

Purification

Protein A Purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

synuclein alpha , NACP , PARK1 , PARK4 , PD1 , SNCA , alpha Synuclein

Cellular Localization

Cytoplasm,Cytosol,Membrane,Nucleus,Cell junction,Synapse,Secreted

Background

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]

Database

Research Area

DATA IMAGES

Anti-alpha Synuclein antibody [AT1E10] used in Western Blot (WB). GTX57587

GTX57587 WB Image

WB analysis of various samples using GTX57587 alpha Synuclein antibody.
Lane 1 : Recombinant Human alpha-synuclein
Lane 2 : Recombinant Human beta-synuclein
Lane 3 : Recombinant Human gamma-synuclein
Loading : 100 ng
Dilution : 1:500

Anti-alpha Synuclein antibody [AT1E10] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX57587

GTX57587 ICC/IF Image

ICC/IF analysis of LNCaP cells using GTX57587 alpha Synuclein antibody.
Blue: DAPI
Green: Primary antibody
Dilution: 1:100

Anti-alpha Synuclein antibody [AT1E10] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX57587

GTX57587 ICC/IF Image

ICC/IF analysis of HeLa cells using GTX57587 alpha Synuclein antibody.
Blue: DAPI
Green: Primary antibody
Dilution: 1:100

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399