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alpha Synuclein antibody [KM51]

Anti-alpha Synuclein antibody [KM51] used in IHC (Paraffin sections) (IHC-P). GTX01946

Cat. No. GTX01946

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 KM51

Isotype

 IgG1

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($519)
See all alpha Synuclein products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:20–1:40

Note :

IHC-P
High temperature antigen unmasking technique using 1 mM EDTA (pH 8.0). Standard ABC technique.
Not tested in other applications.

Calculated MW

14 kDa. ( Note )

Product Note

Does not cross react with beta-synuclein.

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Antigen Species

Human

Immunogen

Prokaryotic recombinant protein corresponding to the majority of the full length alpha-synuclein molecule.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

synuclein alpha , NACP , PARK1 , PARK4 , PD1

Cellular Localization

Cytoplasm , Membrane , Nucleus , Cell junction, synapse , Secreted

Background

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]

Database

Research Area

DATA IMAGES

Anti-alpha Synuclein antibody [KM51] used in IHC (Paraffin sections) (IHC-P). GTX01946

GTX01946 IHC-P Image

IHC-P analysis of human brain, Lewy body dementia using GTX01946 alpha Synuclein antibody [KM51]. Note staining of alpha-synuclein-containing Lewy bodies.

REFERENCE

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REVIEW

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Package List Price ($)
$ 519