*Optimal dilutions/concentrations should be determined by the researcher.
High temperature antigen unmasking technique using 1 mM EDTA (pH 8.0). Standard ABC technique.
Not tested in other applications.
Does not cross react with beta-synuclein.
Tissue culture supernatant, 15 mM sodium azide
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
Batch dependent (Please refer to the vial label for the specific concentration.)
Prokaryotic recombinant protein corresponding to the majority of the full length alpha-synuclein molecule.
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
synuclein alpha , NACP , PARK1 , PARK4 , PD1
Cytoplasm , Membrane , Nucleus , Cell junction, synapse , Secreted
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
GTX01946 IHC-P Image
IHC-P analysis of human brain, Lewy body dementia using GTX01946 alpha Synuclein antibody [KM51]. Note staining of alpha-synuclein-containing Lewy bodies.