APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1 - 2 μg/mL |
| 5 μg/mL |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
Mouse Cerebellum Tissue Lysate(GTX24021)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
alpha Synuclein antibody was raised against a 19 amino acid peptide near the carboxy terminus of human alpha Synuclein.The immunogen is located within the last 50 amino acids of alpha Synuclein.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
synuclein alpha , NACP , PARK1 , PARK4 , PD1
Cellular Localization
Cytoplasm,Membrane,Nucleus,Cell junction, synapse,Secreted
Background
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
Database
Research Area
DATA IMAGES
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GTX31928 WB Image
WB analysis of 1 ng human SNCA recombinant protein using GTX31928 alpha Synuclein antibody.
Working concentration : 1 μg/ml
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GTX31928 IHC-P Image
IHC-P analysis of rat brain tissue using GTX31928 alpha Synuclein antibody.
Working concentration : 5 μg/ml
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GTX31928 WB Image
WB analysis of mouse cerebellum tissue lysate using GTX31928 alpha Synuclein antibody.
Working concentration : 1 μg/ml
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GTX31928 IHC-P Image
IHC-P analysis of rat brain tissue using GTX31928 alpha Synuclein antibody.
Working concentration : 20 μg/ml
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REFERENCE
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REVIEW
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