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beta 2 Microglobulin antibody [B2M/961]

Anti-beta 2 Microglobulin antibody [B2M/961] used in IHC (Paraffin sections) (IHC-P). GTX34437
Anti-beta 2 Microglobulin antibody [B2M/961] used in IHC (Paraffin sections) (IHC-P). GTX34437
Anti-beta 2 Microglobulin antibody [B2M/961] used in IHC (Paraffin sections) (IHC-P). GTX34437

Cat No. GTX34437

Host Mouse
Clonality Monoclonal
Clone Name B2M/961
Isotype IgG2b
Application ICC/IF, IHC-P
Reactivity Human, Primate
Package
100 μg ($429)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
ICC/IF 0.5-1ug/ml
IHC-P 0.5-1ug/ml for 30 minutes at RT

Note :

IHC-P
Boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes

Not tested in other applications.

Calculated MW

14 kDa. ( Note )

Specificity/Sensitivity

Recognizes a protein of 12kDa, identified as β-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an α heavy chain that contains three subdomains (α1, α2, α3) and a non-covalent associating light chain, known as β-2-Microglobulin. β-2-Microglobulin associates with the α3 subdomain of the α heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The α1 and α2 domains of the α heavy chain form the peptide antigen-binding cleft. Mutations in the β-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.
PROPERTIES

Form

Liquid

Buffer

10mM PBS with 0.05% BSA, 0.05% azide (Please contact us for PBS only format)

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml

Antigen Species

Human

Immunogen

Full length recombinant human B2M protein

Purification

Ab purified from Bioreactor Concentrate by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Beta-2-Microglobulin , Imd43 , B2M

Background

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]

Database

Research Area

DATA IMAGES
Anti-beta 2 Microglobulin antibody [B2M/961] used in IHC (Paraffin sections) (IHC-P). GTX34437

GTX34437 IHC-P Image

Formalin-fixed, paraffin-embedded human Melanoma stained with Beta-2-Microglobulin Monoclonal Antibody (B2M/961).

Anti-beta 2 Microglobulin antibody [B2M/961] used in IHC (Paraffin sections) (IHC-P). GTX34437

GTX34437 IHC-P Image

Formalin-fixed, paraffin-embedded human Endometrial Carcinoma stained with Beta-2-Microglobulin Monoclonal Antibody (B2M/961)

Anti-beta 2 Microglobulin antibody [B2M/961] used in IHC (Paraffin sections) (IHC-P). GTX34437

GTX34437 IHC-P Image

Formalin-fixed, paraffin-embedded human Cervical Carcinoma stained with Beta-2-Microglobulin Monoclonal Antibody (B2M/961).

REFERENCE
There are currently no references for beta 2 Microglobulin antibody [B2M/961] (GTX34437). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for beta 2 Microglobulin antibody [B2M/961] (GTX34437). Be the first to share your experience with this product.