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beta Amyloid (1-40) antibody [BAM-10]

Anti-beta Amyloid (1-40) antibody [BAM-10] used in IHC (Paraffin sections) (IHC-P). GTX27501

Cat. No. GTX27501

Reference 6

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 BAM-10

Isotype

 IgG1

Application

 WB, IHC-P, IHC-Fr

Reactivity

 Human, Mouse
Package
500 μl ($399)
See all beta Amyloid products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IHC-P 1:50‐1:100
IHC-Fr Assay dependent
I-ELISA Assay dependent

Note :

IHC-P
Recommendations for antigen retrieval : Citrate Buffer pH 6.0 at room temperature for 30 mins.
Not tested in other applications.

Calculated MW

87 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Ascites

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Antigen Species

Human

Immunogen

A synthetic β-amyloid peptide (1-40) conjugated to KLH.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

amyloid beta precursor protein , AAA , ABETA , ABPP , AD1 , APPI , CTFgamma , CVAP , PN-II , PN2 , preA4

Cellular Localization

Cell membrane , Membrane , Cytoplasmic vesicle , Cytoplasm

Background

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]

Database

Research Area

DATA IMAGES

Anti-beta Amyloid (1-40) antibody [BAM-10] used in IHC (Paraffin sections) (IHC-P). GTX27501

GTX27501 IHC-P Image

IHC-P analysis of human amyloidosis tissue using GTX27501 beta Amyloid (1-40) antibody [BAM-10].

REFERENCE

Clone Reference

Demuth H et al. Front Mol Neurosci 2023; 16:1163087 Deletion of p75NTR rescues the synaptic but not the inflammatory status in the brain of a mouse model for Alzheimer's disease
Application : IHC-Fr
Reactivity : Mouse
F Mantile et al. Immunol Cell Biol 2011; 89 (5):604-9 A multimeric immunogen for the induction of immune memory to beta-amyloid
Application :
Jord?o JF et al. PLoS One 2010; 5 (5):e10549 Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer's disease
Application : WB
Reactivity : Mouse
T Yoshihara et al. J Biochem 2008; 143 (4):475-86 Immunoreactivity of Phage Library-derived Human Single-Chain Antibodies to Amyloid Beta Conformers In Vitro
Application : WB
KP Townsend et al. Eur J Immunol 2005; 35 (3):901-10 CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid beta-peptide
Application : WB
Reactivity : Mouse
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SDS
Sodium Azide.pdf
Package List Price ($)
$ 399