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beta Amyloid (1-40) antibody [BDI350]

Anti-beta Amyloid (1-40) antibody [BDI350] used in Western Blot (WB). GTX40068

Cat. No. GTX40068

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 BDI350

Isotype

 IgG1

Application

 WB, ICC/IF, IHC-P, ELISA

Reactivity

 Human, Rat
Package
50 μg ($409)
See all beta Amyloid products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 μg/ml
ICC/IF 1-10 μg/ml
IHC-P Assay dependent
ELISA 0.1 μg/ml
Not tested in other applications.

Calculated MW

87 kDa. ( Note )

Product Note

Specifically reacts with the C-terminus of Human beta Amyloid 1-40. Does not cross-react with betaAmyloid 1-42.

PROPERTIES

Form

Liquid

Buffer

2X PBS, PEG, Sucrose

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.10 mg/ml (Please refer to the vial label for the specific concentration.)

Immunogen

C-terminal peptide conjugated to KLH.

Purification

Purified by thiophilic adsorption and size exclusion chromatography
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

amyloid beta precursor protein , AAA , ABETA , ABPP , AD1 , APPI , CTFgamma , CVAP , PN-II , PN2 , preA4

Cellular Localization

Cell membrane , Membrane , Cytoplasmic vesicle , Cytoplasm

Background

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]

Database

Research Area

DATA IMAGES

Anti-beta Amyloid (1-40) antibody [BDI350] used in Western Blot (WB). GTX40068

GTX40068 WB Image

WB analysis of Amyloid beta A4 peptides using GTX40068 beta Amyloid (1-40) antibody [BDI350] at 2 μg/mL.
Lane 1: Amyloid beta A4 (1-40)
Lane 2: Amyloid beta A4 (1-42)
Lane 3: Amyloid beta A4 (1-43)

REFERENCE

Clone Reference

R Patnaik et al. Mol Neurobiol 2018; 55 (1):312-321 Histamine H3 Inverse Agonist BF 2649 or Antagonist with Partial H4 Agonist Activity Clobenpropit Reduces Amyloid Beta Peptide-Induced Brain Pathology in Alzheimer's Disease
Application : IHC-P
Reactivity : Rat
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 409