GeneTex
United States (US)

beta Amyloid (1-42) antibody [BDI780]

GTX44420_23_WB_18121410_728.jpg

Cat No. GTX44420

Host Mouse
Clonality Monoclonal
Clone Name BDI780
Isotype IgG1
Application WB, ICC/IF, ELISA
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1 μg/ml
ICC/IF 0.1-1 μg/ml
ELISA 0.05 μg/ml
Not tested in other applications.

Calculated MW

87 kDa kDa. ( Note )

Specificity/Sensitivity

Recognizes the C-terminus of beta Amyloid 1-42. Does not cross-react with beta Amyloid 1-40.
PROPERTIES

Form

Liquid

Buffer

2X PBS, PEG, Sucrose, 0.1% sodium azide

Concentration

0.10mg/ml

Antigen Species

Human

Immunogen

C-terminal peptide conjugated to KLH.

Purification

Purified by thiophilic adsorption and size exclusion chromatography
From tissue culture supernatant

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

ABETA Antibody , APPI Antibody , APP Antibody , AAA Antibody , CVAP Antibody , AD1 Antibody , CTFGAMMA Antibody , PN II Antibody , ABPP Antibody , PN2 Antibody

Cellular Localization

Cell surface protein that rapidly becomes internalized via clathrin-coated pits. During maturation, the immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated).

Background

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
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Database

Research Area

DATA IMAGES
GTX44420_23_WB_18121410_728.jpg

GTX44420 WB Image

WB analysis of Amyloid beta A4 peptides using GTX44420 beta Amyloid (1-42) antibody [BDI780] at 2μg/ml.
Lane 1: Amyloid beta A4 (1-40)
Lane 2: Amyloid beta A4 (1-42)
Lane 3: Amyloid beta A4 (1-43)