*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
Recognizes the C-terminus of beta Amyloid 1-42. Does not cross-react with beta Amyloid 1-40.
2X PBS, PEG, Sucrose, 0.1% sodium azide
C-terminal peptide conjugated to KLH.
Purified by thiophilic adsorption and size exclusion chromatography
From tissue culture supernatant
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
ABETA Antibody , APPI Antibody , APP Antibody , AAA Antibody , CVAP Antibody , AD1 Antibody , CTFGAMMA Antibody , PN II Antibody , ABPP Antibody , PN2 Antibody
Cell surface protein that rapidly becomes internalized via clathrin-coated pits. During maturation, the immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated).
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]