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beta Arrestin 1 antibody [GT1243]

Recombinant antibody Orthogonal
Anti-beta Arrestin 1 antibody [GT1243] used in Western Blot (WB). GTX02840
Anti-beta Arrestin 1 antibody [GT1243] used in Western Blot (WB). GTX02840

Cat. No. GTX02840

Host

 Rabbit

Clonality

 Monoclonal

Clone Name

 GT1243

Isotype

 IgG

Application

 WB

Reactivity

 Human, Mouse
Package
100 μl ($399)
See all beta Arrestin 1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
Not tested in other applications.

Calculated MW

47 kDa. ( Note )

Observed MW

51 kDa. The observed M.W. is based on the following publication. PMID: 17965263

PROPERTIES

Form

Liquid

Buffer

PBS, 0.05% BSA, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, we recommend adding 50% glycerol, then aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein of human ARRB1

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

arrestin beta 1 , ARB1 , ARR1

Cellular Localization

Cytoplasm , Nucleus , Cell membrane , Cytoplasmic vesicle

Background

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]

Database

Research Area

DATA IMAGES

Anti-beta Arrestin 1 antibody [GT1243] used in Western Blot (WB). GTX02840

GTX02840 WB Image

Orthogonal

Various whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with beta Arrestin 1 antibody [GT1243] (GTX02840) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody. Corresponding RNA expression data for the same cell lines are based on Human Protein Atlas program.
The observed M.W. is based on the publication: PMID: 17965263

Anti-beta Arrestin 1 antibody [GT1243] used in Western Blot (WB). GTX02840

GTX02840 WB Image

WB analysis of various samples using GTX02840 beta Arrestin 1 antibody [GT1243].
Dilution : 1:1000
Loading : 25μg

REFERENCE

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REVIEW

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Package List Price ($)
$ 399