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beta Catenin antibody [17C2]

Anti-beta Catenin antibody [17C2] used in IHC (Paraffin sections) (IHC-P). GTX01865

Cat. No. GTX01865

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 17C2

Isotype

 IgG2a

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($629)
See all beta Catenin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:150

Note :

IHC-P
The recommended fixative is 10% neutral-buffered formalin for paraffin-embedded tissue sections. Heat Induced Epitope Retreival (HIER) was performed in Epitope Retrieval Solution pH 9.
Not tested in other applications.

Calculated MW

85 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Antigen Species

Human

Immunogen

Prokaryotic recombinant protein corresponding to a 160 amino acid region of the C-terminus of the beta-catenin molecule.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

catenin beta 1 , CTNNB , EVR7 , MRD19 , armadillo

Cellular Localization

Cytoplasm , Nucleus , Cytoplasm, cytoskeleton , Cell junction , Cell membrane , Cell junction, synapse

Background

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

Database

Research Area

DATA IMAGES

Anti-beta Catenin antibody [17C2] used in IHC (Paraffin sections) (IHC-P). GTX01865

GTX01865 IHC-P Image

IHC-P analysis of human colon polyp using GTX01865 beta Catenin antibody [17C2]. Note the abnormal translocation of the protein to the nucleus.

REFERENCE

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REVIEW

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Package List Price ($)
$ 629