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beta Catenin antibody [4F2]

Anti-beta Catenin antibody [4F2] used in IHC (Paraffin sections) (IHC-P). GTX34339
Anti-beta Catenin antibody [4F2] used in Western Blot (WB). GTX34339

Cat No. GTX34339

Host Mouse
Clonality Monoclonal
Clone Name 4F2
Isotype IgG1
Application WB, IHC-P
Reactivity Human, Mouse, Rat
Package
100 μl ($319)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
IHC-P Assay dependent
Not tested in other applications.

Calculated MW

85 kDa. ( Note )

Specificity/Sensitivity

The antibody detects endogenous Catenin-β protein.
PROPERTIES

Form

Liquid

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant Protein

Purification

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Catenin Beta 1 , Ctnnb , Evr7 , Mrd19 , Armadillo , Ctnnb1

Background

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009]

Database

Research Area

DATA IMAGES
Anti-beta Catenin antibody [4F2] used in IHC (Paraffin sections) (IHC-P). GTX34339

GTX34339 IHC-P Image

Immunohistochemistry (IHC) analysis of paraffin-embedded Human Lung Carcicnoma using Catenin-beta Monoclonal Antibody.

Anti-beta Catenin antibody [4F2] used in Western Blot (WB). GTX34339

GTX34339 WB Image

Western Blot (WB) analysis of 1) HeLa, 2) 293T, 3) Mouse Liver Tissue, 4) Rat Liver Tissue using Catenin-beta Monoclonal Antibody.

REFERENCE
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REVIEW
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Package List Price ($)
$ 319