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beta Catenin antibody [CTNNB1/1507]

Anti-beta Catenin antibody [CTNNB1/1507] used in IHC (Paraffin sections) (IHC-P). GTX34442
Anti-beta Catenin antibody [CTNNB1/1507] used in IHC (Paraffin sections) (IHC-P). GTX34442
Anti-beta Catenin antibody [CTNNB1/1507] used in IHC (Paraffin sections) (IHC-P). GTX34442
Anti-beta Catenin antibody [CTNNB1/1507] used in IHC (Paraffin sections) (IHC-P). GTX34442

Cat. No. GTX34442

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 CTNNB1/1507

Isotype

 IgG1

Application

 IHC-P

Reactivity

 Human, Mouse, Rat
Package
100 μg ($529)
See all beta Catenin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 0.1-0.2μg/ml for 30 min at RT

Note :

IHC-P
Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95ºC followed by cooling at RT for 20 minutes.
Not tested in other applications.

Calculated MW

86 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human beta-Catenin (p120) protein fragment

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CTNNB , CTNNB1 , MRD19 , armadillo , catenin beta 1 , beta Catenin , Catenin-β , β Catenin

Cellular Localization

Cytoplasm,Nucleus,Cytoskeleton,Cell junction,Adherens junction,Cell membrane,Microtubule organizing center,Centrosome,Spindle pole,Synapse

Background

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

Database

Research Area

DATA IMAGES

Anti-beta Catenin antibody [CTNNB1/1507] used in IHC (Paraffin sections) (IHC-P). GTX34442

GTX34442 IHC-P Image

IHC-P analysis of human pancreas tissue using GTX34442 beta Catenin antibody [CTNNB1/1507].

Anti-beta Catenin antibody [CTNNB1/1507] used in IHC (Paraffin sections) (IHC-P). GTX34442

GTX34442 IHC-P Image

IHC-P analysis of mouse colon tissue using GTX34442 beta Catenin antibody [CTNNB1/1507].

Anti-beta Catenin antibody [CTNNB1/1507] used in IHC (Paraffin sections) (IHC-P). GTX34442

GTX34442 IHC-P Image

IHC-P analysis of human tonsil tissue using GTX34442 beta Catenin antibody [CTNNB1/1507].

Anti-beta Catenin antibody [CTNNB1/1507] used in IHC (Paraffin sections) (IHC-P). GTX34442

GTX34442 IHC-P Image

IHC-P analysis of rat colon tissue using GTX34442 beta Catenin antibody [CTNNB1/1507].

REFERENCE

Application Reference

Manule Y et al. Asian Pac J Cancer Prev 2023; 24 (4) : 1413-1417 Prognostic Value of β-Catenin and L1CAM Expressions in Type I Endometrial Carcinoma.
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 529