beta Catenin antibody [CTNNB1/1508]

Cat No. GTX34443

Host	Mouse
Clonality	Monoclonal
Clone Name	CTNNB1/1508
Isotype	IgG1
Application	IHC-P
Reactivity	Human, Mouse, Rat
Package	100 μg ($339)

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Datasheet
Document

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
IHC-P	0.1-0.2μg/ml for 30 min at RT
Note : IHC-P Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95ºC followed by cooling at RT for 20 minutes.

Not tested in other applications.

Calculated MW

86 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA, 0.05% sodium azide (Please contact us for PBS only format)

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human beta-Catenin (p120) protein fragment

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

CTNNB , CTNNB1 , MRD19 , armadillo , catenin beta 1 , beta Catenin , Catenin-β , β Catenin

Cellular Localization

Cytoplasm,Nucleus,Cytoskeleton,Cell junction,Adherens junction,Cell membrane,Microtubule organizing center,Centrosome,Spindle pole,Synapse

Background

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

Database

Gene ID: 1499 CTNNB1
UniProt: P35222 CTNNB1

Research Area

DATA IMAGES

GTX34443 IHC-P Image

IHC-P analysis of human pancreas tissue using GTX34443 beta Catenin antibody [CTNNB1/1508].

GTX34443 IHC-P Image

IHC-P analysis of human tonsil tissue using GTX34443 beta Catenin antibody [CTNNB1/1508].

GTX34443 IHC-P Image

IHC-P analysis of mouse colon tissue using GTX34443 beta Catenin antibody [CTNNB1/1508].

GTX34443 IHC-P Image

IHC-P analysis of rat colon tissue using GTX34443 beta Catenin antibody [CTNNB1/1508].

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf

Package

List Price ($)

100 μg

$ 339

Qty

beta Catenin antibody [CTNNB1/1508]

Cat No. GTX34443

Host

Clonality

Clone Name

Isotype

Application

Reactivity

APPLICATION

Application Note

Calculated MW

PROPERTIES

Form

Buffer

Storage

Concentration

Antigen Species

Immunogen

Purification

Conjugation

Note

TARGET

Synonyms

Cellular Localization

Background

Database

Research Area

DATA IMAGES

GTX34443 IHC-P Image

GTX34443 IHC-P Image

GTX34443 IHC-P Image

GTX34443 IHC-P Image

REFERENCE

REVIEW

Product

Research

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